Journal on Developmental Disabilities
Le journal sur les handicaps du développement

Abstract

Understanding the aberrant biological mechanisms that underlie autism and its spectrum disorders is an exciting challenge for researchers and clinicians because breakthroughs in our understanding of the primary causes of autism are expected to lead to new approaches for intervention, prevention or even cures. This review will highlight some recent advances in our understanding of the causes of autism and of its treatment, including:

• How some forms of autism can actually be prevented
• The possibly changing prevalence of autism
• Problems in diagnosing autism, particularly in very young children, and how such problems can complicate the interpretation of research results
• The many different types of autistic disorders and "double syndromes" that are associated with autistic features
• Different biological abnormalities in autism including abnormalities of neurotransmitters, metabolism, the immune system, and brain structure and function
• Suspected environmental risk factors for autism
• Genetic risk factors for autism
• The importance of animal models for autism
• Therapeutic approaches in autism including medical, intensive early behavioural, educational, and "alternative" interventions

The need for multi-disciplinary teams for clinical assessment and intervention and the plights of individuals with severe autism, especially of older children, adolescents, and adults, are stressed.

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